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For laboratory research use only · Not for human consumptionFree UK next-day delivery
Knowledge journey

Where this sits in the Tirz cluster.

Knowledge journey

  1. collectionGLP-1 Research
  2. commercialTirz UK
  3. guideWhat is Tirz?
  4. guideTirz Mechanism of Action
  5. guideTirz Research
  6. guideTirz Clinical Trials
  7. collectionTirz Collection
  8. collectionTirz Strengths
  9. commercialTirz 10mg
  10. commercialTirz 20mg
  11. commercialTirz 40mg
  12. comparisonRT3 vs Tirz
  13. guideTirz Storage
  14. guideTirz Purity
  15. productBuy Tirz
Commercial hub · UK

Tirz, UK.

The UK commercial hub for research-grade Tirz (LY3298176). Buy Tirz research peptide in the UK with batch-specific COA, ≥99% HPLC purity and temperature-controlled UK dispatch.

BuyRetaUK Tirz research peptide vial
Published
June 2026
Last reviewed
June 2026
Next review
December 2026
Version
v1.1
Reading time
5 min read
Reviewed by
BuyRetaUK Scientific Review Team
Editorial team
BuyRetaUK Editorial Team
Review status
Scientific review complete
Quick answer

In short.

Buy Tirz UK from BuyRetaUK: research-grade Tirz (LY3298176) — a dual GLP-1 / GIP receptor agonist peptide — released at ≥99% HPLC purity with a batch-specific Certificate of Analysis and temperature-controlled UK dispatch. Supplied for in-vitro laboratory research only; not the branded medicines Mounjaro or Zepbound.
Key facts

At a glance.

Product
Tirz (LY3298176)
Compound class
Dual receptor agonist research peptide
Receptors
GLP-1 · GIP
Purity release
≥99% by HPLC-UV
Identity
Mass spectrometry confirmed
COA
Batch-specific, published in the verification library
Dispatch
Temperature-controlled UK storage
Intended use
In-vitro laboratory research only
Important disambiguation

Research material — not Mounjaro or Zepbound.

Tirz is the international non-proprietary name (INN) for the peptide originally developed by Eli Lilly under the code LY3298176. Under its licensed pharmaceutical brands it is sold as Mounjaro (type-2 diabetes) and Zepbound (weight management). Those are prescription medicines regulated by national medicines authorities.

BuyRetaUK does not supply Mounjaro or Zepbound. We supply research-grade Tirz as a laboratory chemical for in-vitro use only. Nothing on this site is medical advice, a prescription, or an offer to sell a medicinal product.

Choose your dose

Available strengths.

Every vial ships with a batch-specific COA · UK dispatch

Before you buy

Buying considerations.

  • Purity release ≥99% HPLC-UV

    Every batch is independently released against a ≥99% HPLC-UV specification with mass-spec identity.

  • Batch-specific COA

    Cross-reference the batch number printed on your vial against the COA in the verification library.

  • Temperature-controlled UK dispatch

    Picked, packed and shipped under cold-chain protocols from our UK facility.

  • In-vitro research use only

    Supplied strictly for laboratory research. Not a medicine — not Mounjaro or Zepbound.

  • Reconstitution guidance

    Volumes for any concentration are handled by our reconstitution calculator.

  • Transparent scientific references

    Every claim cites primary literature — see the References section below.

Decision support

Which product is right for my research?

Research scenarioRecommendedRationale
Dual GLP-1 / GIP receptor researchTirzThe reference dual-incretin agonist — the primary tool compound for GIP + GLP-1 co-activation studies.
Triple-receptor incretin studies (GLP-1 / GIP / Glucagon)RT3Adds glucagon receptor activation on top of dual GLP-1/GIP — the next step up from Tirz.
Single GLP-1 receptor baselineSemaLong-acting single-receptor GLP-1 comparator — the standard baseline.
Reconstitution / dilutionBacteriostatic WaterStandard diluent for reconstituting lyophilised peptides.
Specifications

Product specifications.

INN
Tirz
Research code
LY3298176
Class
Dual receptor agonist research peptide
Receptors
GLP-1 · GIP
Form
Lyophilised powder
Available strengths
10 mg · 20 mg · 40 mg
Purity release
≥99% by HPLC-UV
Identity
Mass spectrometry confirmed
Storage (lyophilised)
2–8 °C, protected from light
Storage (reconstituted)
Refrigerated; use within 30 days
Documentation
Batch-specific COA (public library)
Intended use
In-vitro laboratory research only
Why BuyRetaUK

Tirz, sourced and dispatched from the UK.

BuyRetaUK is a UK-based research-peptide supplier. Every Tirz batch is treated as a reference specimen: independent HPLC-UV purity confirmation, mass-spec identity, endotoxin data where determined, and a batch-specific Certificate of Analysis published in our public verification library.

Orders are picked, packed and dispatched from UK-based temperature-controlled storage under cold-chain protocols with tracked delivery. See our shipping policy for current cut-off times and packaging detail.

All BuyRetaUK products are supplied strictly for in-vitro laboratory research. We do not offer, market or discuss human or veterinary administration.

Laboratory quality

Quality standards.

Pair with

Common comparators & consumables.

Tirz is frequently referenced alongside RT3 (triple GLP-1 / GIP / glucagon) and Sema (single GLP-1) as the triple / dual / single incretin reference set. See RT3 vs Tirz for the canonical side-by-side. Most laboratories also stock bacteriostatic water for reconstitution — dose volumes are handled by our reconstitution calculator.

Frequently asked questions

FAQs.

Is BuyRetaUK selling Mounjaro or Zepbound?[+]

No. Mounjaro and Zepbound are Eli Lilly's branded prescription medicines that contain Tirz. BuyRetaUK supplies research-grade Tirz (LY3298176) as a laboratory research material only. We do not sell, market or offer branded medicines.

Is Tirz legal to buy in the UK for research?[+]

Yes — BuyRetaUK supplies Tirz as a research chemical for in-vitro laboratory use only. It is not offered for human or veterinary administration.

What purity does BuyRetaUK release Tirz at?[+]

≥99% by HPLC-UV, with identity confirmed by mass spectrometry. Each batch ships with a batch-specific Certificate of Analysis published in our verification library.

How is Tirz shipped in the UK?[+]

Dispatched from temperature-controlled UK storage under cold-chain protocols with tracked delivery. See our shipping policy for current cut-off times and packaging.

How does Tirz compare to RT3?[+]

Tirz is a dual agonist (GLP-1 / GIP). RT3 is a triple agonist (GLP-1 / GIP / glucagon). Both are supplied as lyophilised research peptides at ≥99% HPLC. See our RT3 vs Tirz comparison guide.

References

Scientific sources & further reading.

  1. [1]Coskun T. et al. (2018) LY3298176, a novel dual GIP and GLP-1 receptor agonist for the treatment of type 2 diabetes mellitus: From discovery to clinical proof of concept. Molecular Metabolism, 18 DOI: 10.1016/j.molmet.2018.09.009DOI →
  2. [2]Frías J.P. et al. (2021) Tirz versus Sema Once Weekly in Patients with Type 2 Diabetes (SURPASS-2). New England Journal of Medicine, 385(6) DOI: 10.1056/NEJMoa2107519DOI →
  3. [3]Jastreboff A.M. et al. (2022) Tirz Once Weekly for the Treatment of Obesity (SURMOUNT-1). New England Journal of Medicine, 387(3) DOI: 10.1056/NEJMoa2206038DOI →

Peer-reviewed citations are added as each article is expanded. See our editorial standards for our sourcing and accuracy commitments.

Editorial team
BuyRetaUK Editorial Team
Author · BuyRetaUK

The BuyRetaUK editorial team publishes laboratory-focused reference content on research peptides, analytical methods and Certificates of Analysis. All articles are written for in-vitro research contexts only.

View profile →
Scientific reviewer
BuyRetaUK Scientific Review Team
Scientific reviewer

Every editorial article is reviewed against our accuracy commitment and quality-assurance checklist before publication. Named reviewer profiles are added as our reviewer network expands.

View profile →
Editorial standards

How this content is produced.

Every article follows a documented editorial process — sourcing, scientific review, update cadence and correction policy — so researchers can rely on what we publish.

Read the full editorial standards →
Commercial journey

Your research-to-checkout journey.

Educational first. Each step is optional — start wherever you are in your research.

  1. Step 1ResearchUnderstand mechanism, class and study context.
  2. Step 2ComparisonSee how compounds differ in receptor profile.
  3. Step 3Laboratory qualityHPLC-UV purity, mass-spec identity, endotoxin data.
  4. Step 4Certificates of analysisVerify your batch in the public COA library.
  5. Step 5ProductsChoose a strength — every vial ships with COA.
  6. Step 6CheckoutEncrypted checkout, temperature-controlled UK dispatch.
Recommended reading path

How to research this topic.

Recommended reading path

  1. Step 01
    Start here — What is Tirz?

    Dual GIP/GLP-1 receptor overview and research framing.

  2. Step 02
    Mechanism of action

    How dual receptor engagement drives the incretin response.

  3. Step 03
    Research landscape

    Published evidence base, SURPASS & SURMOUNT programmes, laboratory applications.

  4. Step 04
    Clinical trial evidence

    Phase 3 SURPASS & SURMOUNT read-outs and the peer-reviewed literature.

  5. Step 05
    Compare with RT3

    Dual vs triple incretin agonist — how they differ.

  6. Step 06
    Verify a batch

    HPLC purity and Certificate of Analysis verification.

  7. Step 07
    Storage & reconstitution

    Lyophilised storage, bacteriostatic water reconstitution, in-use stability.

  8. Step 08
    Browse strengths

    Every Tirz vial strength available.

  9. Step 09
    Buy Tirz

    UK commercial hub — lab data, COAs and dispatch.

Knowledge Hub
Comparisons
Batch verification

Every batch of Tirz ships with a third-party HPLC and mass-spec Certificate of Analysis. Browse the live COA library to verify your lot.

Next steps

Continue your research.